Regular exercise modulates cardiac mast cell activation in ovariectomized rats
نویسندگان
چکیده
منابع مشابه
Moderate intensity of regular exercise improves cardiac SR Ca2+ uptake activity in ovariectomized rats.
The impact of regular exercise in protecting cardiac deteriorating results of female sex hormone deprivation was evaluated by measuring changes in intracellular Ca2+ removal activity of sarcoplasmic reticulum (SR) in ovariectomized rats following 9-wk treadmill running exercise at moderate intensity. Despite induction of cardiac hypertrophy in exercised groups of both sham-operated and ovariect...
متن کاملRegular exercise improves cardiac contractile activation by modulating MHC isoforms and SERCA activity in orchidectomized rats.
Data from the trial known as Testosterone in Older Men with Mobility Limitations (TOM) has indicated an association between testosterone administration and a greater risk for adverse cardiovascular events. We therefore propose that regular exercise is a cardioprotective alternative that prevents detrimental changes in contractile activation when a deficiency in male sex hormones exists. Ten-wee...
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The objective of this study was to determine whether elevated circulating levels of endothelin (ET)-1 are capable of mediating left ventricular (LV) mast cell degranulation and thereby induce matrix metalloproteinase (MMP) activation. After the administration of 20 pg/ml ET-1 to blood-perfused isolated rat hearts, LV tissue was analyzed for signs of mast cell degranulation and MMP activation. R...
متن کاملEvidence for mast cell activation during exercise-induced bronchoconstriction.
Controversy remains about the causative mediators in the bronchoconstrictive response to exercise in asthma. This study examined whether mast cell activation is a feature of exercise-induced bronchoconstriction by measuring urinary metabolites of mast cell mediators. Twelve nonsmoking subjects with mild asthma and a history of exercise-induced bronchoconstriction exercised on a stationary bicyc...
متن کاملInvolvement of microRNA-133 and -29 in cardiac disturbances in diabetic ovariectomized rats
Objective(s): Menopause and diabetes obviously increase the risk of cardiovascular disease in women. The aims of the present study were to evaluate the effects of ovariectomy in type 2 diabetes on the histology and expression of miRNA-29, miRNA-133, IGF-1 and Bcl-2 genes and Bcl-2 protein and caspase 3 activity in the hearts of female rats. Materials and Methods: Forty Female Wistar rats were ...
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ژورنال
عنوان ژورنال: The Journal of Physiological Sciences
سال: 2015
ISSN: 1880-6546,1880-6562
DOI: 10.1007/s12576-015-0409-0